FIELD: medicine.
SUBSTANCE: group of inventions is related to medicine and pharmacology. One proposes application of afobazole {5-ethoxy2-[2-(morpholino)ethylthio]-benzimidazole dihydrochloride}, anxiolytic, as an agent for preventing and treating diabetes and use of the main metabolite afobazole, connection of m-11, 2-[2-(3-oksomorfolin-4-YL) ethylthio]-5-ethoxybenzimidazole also as an agent for preventing and treating diabetes. It is shown that afobazole and connection of the m-11 inhibit depeptidylpeptidase-IV (DPP-4), without affecting other activity prolin specific enzymes. Hypoglycemic activity of afobazole can be caused by not only starting substance and its main metabolite. Set of obtained results combined with multiple clinical data on good tolerance this anxiolytic make it possible to consider application according to the new reading-as an agent preventing developing diabetes.
EFFECT: technical result: afobazole provides manifested hypoglycemic effect on the background hyperglycemia and tolerance to glucose load; the main metabolite afobazole, connection of m-11, exhibits angihyperglycemic effect, the intensity of which is lower than for afobazole.
2 cl, 5 tbl, 2 dwg
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