PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS Russian patent published in 2016 - IPC A61K31/675 C07F9/58 C07F9/6558 C07F9/6509 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to compounds of formula (I) and based on it composition used in medicine at abnormal cell growth

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where Y is N or CR⁶; L¹ and L² are independently selected from a linking of -R⁶NR⁷-, -R⁶OR⁷-, -R⁶SR⁷-, alkyl, C_5-6-carbocycle and 5-6-member heterocycle containing 1-2 heteroatoms selected from nitrogen; where L¹ and L² can be connected to any position; W¹ is selected from C_6-12-aryl, optionally substituted by 1-3 halogens, in case when C_6-12-aryl is substituted with only two substitutes, these two substitutes are not placed in para positions; W² is selected from C_6-12-aryl and 5-6-member heteroaryl containing 1-2 heteroatoms selected from nitrogen, optionally substituted by halogen, -OR⁶, -SR⁶, -N(R⁶)R⁷, alkyl or alkyl substituted by halogen; R¹ is selected from a group consisting of hydrogen and halogen; R² and R³ are selected from hydrogen, halogen and alkyl; and R⁴ and R⁵ are independently selected from -OR⁶ and alkyl; where R⁶ and R⁷ are selected from hydrogen, halogen and C_1-12-alkyl.

EFFECT: new substances modulating protein kinase activity and applicable for treating oncological diseases, ALK or cMet mediated disorders are suggested, including by EML4-ALK mediated fused protein having at least one mutation selected from L1196M, R1275Q and F1174L.

33 cl, 29 ex