NEW SUBSTITUTED QUINOLINE COMPOUNDS AS INHIBITORS OF S-NITROZOGLUTATION-REDUCTASE INHIBITORS Russian patent published in 2016 - IPC C07D215/227 C07D401/10 C07D401/14 C07D409/04 C07D409/14 C07D413/10 C07D417/10 A61K31/4709 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention is related to organic chemistry and specifically to novel quinoline derivatives of general formula I or pharmaceutically acceptable salts, stereoisomers or N-oxides, where m = 0 and 1; R₁ is independently selected from a group consisting of chlorine, fluorine and bromine; R_2b and R_{2 c} are independently selected from a group, consisting of hydrogen, halogen, C₁-C₃ alkyl, fluorinated C₁-C₃alkyl, cyano and N (CH₃)₂; X is selected from a group consisting of n is selected from a group consisting of 0 and 1; R₃ is independently selected from a group consisting of halogen, C₁-C₃ alkyl, fluorinated with₁-C₃ alkyl, cyano, C₁-C₃alkoxy and NR₄R_4′, where R₄ and R_4′ are independently selected from a group consisting of C₁-C₃ alkyl; and a is selected from a group consisting of .Invention is also related to the use of formula I, pharmaceutical composition based on the compound of formula I, method of treating pulmonary disorders and inflammatory diseases based on use of the compound of formula I, and a method of producing a pharmaceutical composition based on the compound of formula I.

EFFECT: technical result is obtaining novel quinoline derivatives, useful as inhibitors of S-nitrozoglutation reductase (GSNOR).

17 cl, 64 ex