FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely a benzimidazole-2-piperazine derivative of general formula (I), wherein R is fluorine; one of X, Y, Z is nitrogen, and two others – hydrocarbons, or X, Y, Z-hydrocarbons; R1 – hydrogen, methoxy, trifluoromethyl, halogen, cyano, CONR2R3 and NR2R3; R2 – hydrogen, C1-C6-alkyl; R3 – hydrogen, C1-C6-alkyl, or NR2R3 together form a cycle of morpholine, pyrrolidine. Invention also relates to a method of producing the compound of formula (I).
(I).
EFFECT: new derivatives were obtained as a poly(ADP-ribose)-polymerase (PARP) inhibitor.
4 cl, 1 tbl, 41 ex
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