FIELD: chemistry.
SUBSTANCE: present invention relates to novel inhibitors of S-nitrosoglutathione reductase (GSNOR) of formula I, wherein X is selected from a group consisting of O and S; Y is selected from a group consisting of O and S; Z is selected from a group consisting of Z1, Z2, Z3 and Z4, wherein Z1 denotes 
, Z2 denotes 
, Z3 denotes 
and Z4 denotes 
, with the proviso that Z is only Z4, when at least one of X or Y is S; R1 is selected from a group consisting of hydrogen, (C1-C6) alkyl, (C1-C6) haloalkyl; R2 is selected from a group consisting of hydrogen, halogen; R3 is selected from a group consisting of hydrogen, halogen; R4 is selected from a group consisting of tetrazole, oxadiazolone, thiadiazolone, methylsulphonylcarbamoyl and N-hydroxycarbamoyl; and R5 is selected from a group consisting of carboxy, tetrazole or a pharmaceutically acceptable salt thereof, and to pharmaceutical compositions containing such inhibitors of GSNOR, and their use.
EFFECT: providing pharmaceutical compositions.
16 cl, 24 ex
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