METHOD OF ACTIVATION OF REGULATORY T-CELLS OF ALPHA-2B ADRENERGIC RECEPTOR AGONISTS Russian patent published in 2016 - IPC A61K31/17 A61K31/4164 A61K31/4168 A61K31/4178 A61K31/421 A61P1/00 A61P3/10 A61P11/06 A61P17/00 A61P19/02 A61P37/00

Abstract RU 2599495 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to ophthalmology, and can be used for treating dry eye disease. Ensured by introducing an agonist of Alpha-2B receptors, which is selected from group consisting of: imidazoline or imidazole. Group of inventions also refers to treating dry eye disease with alpha-2 receptor agonists of patient with lack of agonist of Alpha-2A receptors substantial activity.

EFFECT: using this group of inventions, namely above compounds, triggers mechanism immunomodulation by regulation of t-cells, reducing cytokine IL-17 and TNF, reducing loss of goblet cells.

4 cl, 12 dwg, 4 tbl

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RU 2 599 495 C2

Authors

Dzhil Deniel V.

Donello Dzhon E.

Lurs Loren M.B.

Visvanat Veena

Dates

2016-10-10—Published

2011-08-11—Filed