FIELD: medicine.
SUBSTANCE: group of inventions discloses a group of antibodies and their antigen-binding fragments specifically binding to human oncostatin M (OM), as well as pharmaceutical compositions containing said antibodies and antigen-binding fragments, for treating or preventing OM-associated conditions, such as osteoarthritis and idiopathic pulmonary fibrosis.
EFFECT: antibody and antigen-binding fragments according to group of inventions block signal receptors gp130 and, respectively, exert a clinically useful cytotoxic or immunomodulatory action on gp130 expressing cells.
22 cl, 10 dwg, 13 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MOLECULES WHICH BIND TO 4-1BB | 2011 |
|
RU2710717C2 |
| ANTI-GM-CSF ANTIBODIES AND USING THEM | 2006 |
|
RU2447085C2 |
| BLOCKING ANTI-Dkk-1 ANTIBODIES AND APPLICATIONS THEREOF | 2010 |
|
RU2548817C2 |
| ANTIBODIES TO MST1R AND THEIR APPLICATION | 2010 |
|
RU2534890C2 |
| ANTI-C5 ANTIBODIES AND THEIR USE | 2018 |
|
RU2774716C2 |
| RECOVERED IP-10 ANTIBODY, IMMUNOCONJUGATE AND BIOSPECIFIC MOLECULE THEREOF, COMPOSITIONS THEREOF, METHOD OF TREATING (VERSIONS), CODING MOLECULE OF NUCLEIC ACID, RELATIVE EXPRESSION VECTOR, HOST CELL AND HYBRIDOMA | 2004 |
|
RU2486199C2 |
| NR10 ANTIBODY AND USING IT | 2008 |
|
RU2531521C2 |
| ADVANCED ANTIBODY MOLECULES | 2009 |
|
RU2430111C1 |
| ANTIBODIES TO INTERLEUKIN-6 AND USES THEREOF | 2013 |
|
RU2656162C2 |
| HUMANISED ANTI-IL-10 ANTIBODIES FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | 2010 |
|
RU2587622C2 |
