FIELD: chemistry.
SUBSTANCE: claimed invention relates to field of biotechnology, namely to obtaining stable liquid etanercept composition, and can be used in medicine. Liquid composition of etanercept -recombinant sTNFR p75:Fc fusion protein, consisting in fact of etanercept and stabiliser: methionine, lysine and/or histidine, is obtained. Stabiliser is present in quantity from 0.1 to 250 mM.
EFFECT: invention makes it possible to obtain composition with increased etanercept storage stability in comparison with composition, which does not have stabilisers, due to reduction of etanercept by-products, formed as a result of denaturation in the process of storage.
14 cl, 10 tbl, 4 ex
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