METHOD OF PRODUCING RADIOPHARMACEUTICALS OF POLY-N-VINYLAMIDES CLASS WITH METALS OF MANGANESE GROUP Russian patent published in 2016 - IPC C08F226/10 C08F8/42 A61K49/00 A61K51/06 A61K103/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing radiopharmaceuticals class poly-N-vinylamides with metals of manganese subgroup. Method involves synthesis of a radioisotopes-carrier polymer containing amino groups and performing radio-labelling. Polymer-carrier used is a water-soluble copolymer of N-vinylpyrrolidone with vinyl/allylamine with the molecular weight of 3,000-60,000 Da, the content of N-vinylpyrrolidone of m=20-70 mol% and vinyl/allylamine of n=80-30 mol%, the content of primary amino groups of 5-25 mol%. Radioisotope used are compounds of transition metals in the form of permetallates (MO₄ ^-): ^99mTcO₄ ^- or ^{186, 188}ReO₄ ^-. Herewith the reaction of the copolymer-carrier with the radioisotope is performed by direct incorporation in water or an aqueous-alcoholic solution in an inert gas atmosphere at the temperature of 30-97 °C, pH 1÷5.5 and the concentration of the copolymer-carrier in the solution of 5-20 wt% for 0.1-1.0 hours to produce a metal-polymer conjugate of the following general formula: , where m, n are the numbers of repeating links of N-vinylpyrrolidone and vinyl/allylamine respectively x=0, 1, M=^99mTc, ^{186, 188}Re.

EFFECT: invention enables to obtain hybrid water-soluble macromolecular carriers of radioisotopes used for organism neoplasm diagnostics by single-photon emission tomography methods.

1 cl, 5 ex