PEPTIDES MARKED WITH RADIOACTIVE ISOTOPES FOR DIAGNOSING AND TREATING DISEASES Russian patent published in 2001 - IPC

FIELD: medicine. SUBSTANCE: method involves applying receptor-binding vasoactive intestinal peptide bound in covalent way to chelating component of technetium or rhenium. Derivatives of receptor-binding vasoactive intestinal peptides marked with technetium-99m are used as scintigraphic reflecting agents. Derivatives of receptor-binding vasoactive intestinal peptides and vasoactive intestinal peptide analogs marked with cytotoxic radioactive isotopes like rhenium-186 (¹⁸⁸Re) or rhenium-188 (¹⁸⁸Re) are used as radiotherapy agents. EFFECT: improve production method; wide range of radiological and therapeutical application fields. 11 cl, 5 tbl