THERMOSENSITIVE POLYMER-PROTEIN IODINE-CONTAINING RADIOPHARMACEUTICAL Russian patent published in 2015 - IPC A61K51/00 A61K51/06 A61K51/08 A61K101/02 

FIELD: chemistry.

SUBSTANCE: invention represents method of obtaining thermosensitive iodine-containing radiopharmaceutical (RP) with radiochemical purity 95-98%, consisting in covalent binding of radioactive iodine isotopes to tyrosine groups, included into chain of poly-N-isopropylacrylamide, with further separation of labelled polymer component from low molecular compounds on chromatographic gel column by elution with water, characterised by the fact that as mobile phase used are water solutions of chemical compounds, mainly inorganic salts, possessing coefficient of polymer-hydrate-iodine complex $$\gamma =-\frac{d{T}_{ft}}{d{C}_s}$$ destabilisation from the interval γ=30-60 degree·l/mol, where T_ft is temperature of phase transition in solution, containing destabilising additive, C_s is concentration of additive, limited from above by condition $$\gamma \cdot C_s<T_{ft}^0-T_{к}$$ ( $$T_{ft}^0=T_{ft}$$ , at C_s=0, T_c is temperature in column).

EFFECT: creation of RP with high radiochemical frequency and reduction of radioactive pollution of the environment.

6 dwg, 2 tbl, 9 ex