METHOD OF OBTAINING ERYTHROMYCIN TABLETS Russian patent published in 2010 - IPC A61K31/7048 A61K47/00 A61K9/20 A61J3/10 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: method of obtaining erythromycin tablets consists in the following: mixture of erythromycin and polyvinylpyrrolidone with molecular weight 10000±2000 with their weight ratio 1:0.125-2 is dissolved in ethanol. Ratio of alcohol and erythromycin and polyvinylpyrrolidone mixture constitutes 1:3-7. After that solution is introduced into device for granulate drying, solvent is removed at temperature 37-41°C. To obtained mass with weight ratio of components 1:2-4 added is mixture of microcrystalline cellulose, starch, lactose, taken with weight ratio 1:2.5-3:6.5-7, respectively. Magnesium stearate is introduced into mixture in amount 2-3% of granulate weight and mixture is tabletted.

EFFECT: claimed method of obtaining erythromycin tablets allows to increase its bioavailability and antibacterial activity.

1 dwg, 3 tbl, 2 ex