FIELD: pharmaceutics.
SUBSTANCE: present invention relates to a compound and its pharmaceutically or cosmetically acceptable salts, used as an inhibitor of sodium-dependent glucose co-transporter, antioxidant and for depigmenting the skin in medicine and cosmetology, of the following formula (I):
,
as well as methods of its production and compositions based thereon, where n, m and p are independently 0 or 1, R denotes CH2OH or CH2OR11,R1 and R2 are OH or OR15, R3 is OH or OR18, R4 is a hydrogen atom, when n=1, or a hydrogen atom, a halogen atom or OH group, when n=0; X1 is a hydrogen atom, halogen atom, OH group, (C1-C6)-alkyl or OR24; U, V and W denote phenyl, pyrazolyl, N-(C1-C6)alkyl-pyrazolyl or thienyl optionally substituted by one or more substitutes selected from a halogen atom, OH, (C1-C6)-alkyl and OR24; R11, R15 and R18 are aryl-(C1-C6)-alkyl and R24 is (C1-C6)-alkyl or aryl-(C1-C6)-alkyl. In the proposed methods a compound of formula (II) is fluoridated, or compounds of formulae (VIII) and (XI)
, 
are bound, wherein OH group in position of R4 in the binding product of formula (I) is optionally substituted by halogen, or the compound of formula (I) is bromated with subsequent reconstruction, or a compound of formula (XVI) is associated with a compound of formula (V), where R, R1, R2, R3, X1, U, V, W, n, m and p are given above, A1 is -Li or -Mg-Hal, Hal is a halogen atom, R9 is a leaving group.
EFFECT: new agent is disclosed which is suitable for bleaching and depigmentation of skin, as an antioxidant, for inhibition of sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, and diseases, where such inhibition is effective, in particular in the treatment or prevention of diabetes and diabetes-related complications.
21 cl, 69 ex, 11 dwg
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