DESTRUCTION-RESISTANT DOSAGE FORM CONTAINING AN INORGANIC SALT Russian patent published in 2016 - IPC A61K9/16 A61K9/20 A61K47/02 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutics, namely to a pharmaceutical dosage form with breaking strength of at least 500 N, mentioned dosage form contains pharmacologically active component (A); inorganic salt (B), where inorganic salt (B) is sodium carbonate or five-substituted sodium triphosphate or mixture of them, and content of inorganic salt (B) ranges from 15 to 40 wt%, based on total weight of dosage form; and polyalkylene oxide (C), having weight-average molecular weight of at least 200.000 g/mol, where content of polyalkylene oxide (C) is at least 30 wt% of total weight of dosage form; where pharmacologically active component (A) is present in controlled-release matrix containing inorganic salt (B) and polyalkylene oxide (C) and where in vitro, release profile of pharmacologically active component (A) from mentioned matrix includes at least, time interval during which release corresponds to zero-order kinetics.

EFFECT: stated pharmaceutical dosage form is suitable for avoiding abuse of pharmacologically active component, which is contained in it.

10 cl, 3 ex, 5 dwg