DESTRUCTION-RESISTANT DOSAGE FORM CONTAINING ANIONIC POLYMER Russian patent published in 2017 - IPC A61K9/16 A61K9/20 A61K31/00 A61K47/30 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutics, namely to dosage form in form of tablets with tensile strength of at least 500 N containing pharmacologically active component (A) selected from hydrocodone, hydromorphone, morphine, oxycodone, oxymorphone, tramadol and their pharmaceutically acceptable salts; polymer (B) selected from (i) homopolymer of acrylic acid, cross-linked allyl sucrose or allyl pentaerythritol, or (ii) copolymer of acrylic acid and C₁₀-C₃₀-alkyl-acrylate, cross-linked allyl pentaerythritol, or (iii) interpolymer selected from homopolymers of acrylic acid, cross-linked allyl sucrose or allyl pentaerythritol, and copolymers of acrylic acid and C₁₀-C₃₀-alkyl-acrylate, cross-linked allyl pentaerythritol containing copolymer block of polyethylene glycol and ester of C₈-C₃₀-alkyl acid; and from 30 to 90 wt% of polyethylene oxide (C) with average molecular weight from 2,500,000 to 15,000,000 g/mol, wherein component (A) is present in controlled-release matrix containing polymer (B) and polyethylene oxide (C).

EFFECT: invention provides production of destruction-resistant dosage forms with prolonged release of active component.

5 cl, 8 ex, 19 tbl, 16 dwg