C-MET INHIBITORS AND THEIR APPLICATION Russian patent published in 2011 - IPC C07D487/04 C07D513/04 C07D519/00 A61K31/433 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds (la) of formula applied as tyrosine kinase c-Met inhibitors. , where: L^A is selected from ,

or ; R^A is selected from:

or each R^A2 and R^A6 represents hydrogen; R^A3 represents R^Ar; or R^A3, R^A4 and carbon atoms whereto attached form 6-members aryl, optionally substituted, in the amount up to 4 by independent groups R^Ar, or a 5-6-members heterocyclyl or heteroaryl ring containing at least one O, N or S atom; R represents -OH; R^A5 represents hydrogen or R^Ar; L^B represents a covalent bond or -N(R*)-; R^B represents halogen, NH₂ or C_1-8aliphatic group, optionally substituted by R; a 6-10-members aryl ring; a 3-7-members carbocyclyl ring, a 5-10-members heteroaryl ring containing 1-4 heteroatoms independently selected from nitrogen, oxygen and sulphur atoms, where each said aryl or heteroaryl ring is optionally substituted, in the amount up to five by independent groups R^Ar; R represents halogen, -R°, -SR°, Ph, optionally substituted R° or -C(O)OR°; each R^Ar is independently selected from halogen, -R°, -OR^°, -SR°, Ph, optionally substituted in the amount up to five by independent groups -R°, -CN, -N(R°)₂ or -C(O)OR°; or two adjacent groups R^Ar taken together, represent 1,2-methylenedixy or 1,2-ethylenedixy; each R* represents hydrogen; and each R° represents independently hydrogen, an optionally substituted C_1-6aliphatic radical or an unsubstituted 5-6-members heteroaryl or heterocyclic ring containing 1-3 heteroatoms independently selected from nitrogen, oxygen and sulphur atoms.

EFFECT: invention refers to pharmaceutically acceptable compositions containing the compounds under the invention, and methods of application of the compositions in treatment of various proliferative disorders.

10 cl, 4 tbl, 548 ex, 9 dwg