FIELD: medicine; immunology.
SUBSTANCE: preset invention relates to immunology. Disclosed is an isolated anti-IL-17F antibody and an antigen-binding fragment thereof, which are characterised by CDR sequences for heavy and light chains. A method of producing an antibody according invention and an antigen-binding fragment thereof is disclosed. Furthermore, based on use of antibody according to present invention and antigen-binding fragment thereof, a pharmaceutical composition is provided, as well as a method of alleviating a symptom of an autoimmune disease or an inflammatory disorder and a method of alleviating a symptom of the arthritis condition in a subject.
EFFECT: present invention can be further used in treatment of diseases associated with elevated levels of IL-17F.
23 cl, 2 dwg, 4 tbl, 7 ex
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