METHOD FOR ASSESSING RISK OF PROGRESSION OF CHRONIC RENAL DISEASE IN CHILDREN Russian patent published in 2016 - IPC G01N33/50 C12Q1/68 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and aims at evaluating of risk of progression of chronic renal disease (CRD) in children. Blood is sampled from peripheral vein in child with suspected CRD and using allele-specific polymerase chain reaction single-nucleotide polymorphisms of angiotensin converting enzyme (ACE) Alu Ins/Del I > D are identified, angiotensin (AGT) Thr174Met and Met235Thr, type 1 angiotensin 2 receptors (R1AGT) C1166C and endothelin-1 (ET-1) Lys198Asn. If observing Alu Ins/Ins ACE and Thr174Met AGT, risk of CRD progressing is estimated as light. If observing Met174Met AGT and Alu Ins/Del ACE, risk of CRD progressing is estimated as average. If observing combination of single-nucleotide polymorphisms, Thr235Thr AGT, C1166C R1AGT, Lys198Asn ET-1 and Alu Del/Del ACE risk of CRD progressing is estimated as high.

EFFECT: invention enables high-reliability assessment of risk of CRD progressing in children on basis of early detection of genetic predictors - nucleotide polymorphisms of genes.

1 cl, 3 ex