METHOD OF TREATING PREGNANT WOMEN WITH CHRONIC KIDNEY DISEASE Russian patent published in 2024 - IPC A61K31/12 A61K31/13 A61P13/12 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, can be used in clinical nephrology and concerns a method of treating pregnant women with stage 4 chronic kidney disease. Additionally, starting from 12th week, preparations of ketone analogues of amino acids are used in dose of 6 tablets in 3 divided doses with food and acetylsalicylic acid in dose of 150 mg a day in the morning once, under daily control of blood pressure and proteinuria level twice a month. Every month, the patient undergoes blood analysis for creatinine, urea, potassium with assessment of glomerular filtration rate according to CKD-EPI. At the same time, if according to the results of the monthly analyses, there is no increase in creatinine, urea and potassium, absence of glomerular filtration rate decrease in comparison with the data obtained before the beginning of treatment, the treatment regimen is prolonged, leaving unchanged for another 1 month. If the results of the monthly analyses show no stabilization of parameters of nitrogenous wastes and a decrease in the glomerular filtration rate compared to the data obtained before the beginning of the treatment, the therapeutic regimen includes dipyridamole up to 75 mg a day. Treatment according to the above schemes is carried out till 37th week of pregnancy, and after 37th week of pregnancy, the preparation of ketone analogues of amino acids is left.

EFFECT: use of the method allows prolonging pregnancy up to 38 weeks in patients with chronic renal diseases of stage 4 and maintaining their function and survival rate, to give birth to a full-term mature baby not in need of nursing and resuscitation.

1 cl, 2 ex