METHOD FOR PREDICTION OF PROGRESSIVE CLINICAL COURSE OF GLOMERULONEPHRITIS IN CHILDREN Russian patent published in 2025 - IPC G01N33/50 C12Q1/6827 C12Q1/686 C12Q1/6883 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to paediatrics, and can be used for prediction of progressive clinical course of glomerulonephritis in children. Single-nucleotide polymorphism of endothelin-1 (Lys198Asn), interleukin-4 (C-589T) and tumour necrosis factor (G308A) genes is determined in peripheral blood cells. When detecting allele 198Asn of the endothelin-1 gene, the allele -589T of the interleukin-4 gene and allele 308A of the tumour necrosis factor gene; allele 198Asn of endothelin-1 gene and allele -589T of interleukin-4 gene; allele 198Asn of endothelin-1 gene and allele 308A of tumour necrosis factor gene; allele -589T of interleukin-4 gene; allele -589T of interleukin-4 gene and allele 308A of tumour necrosis factor gene; allele 198Asn of endothelin-1 gene, predict progressive clinical course of glomerulonephritis in children.

EFFECT: method provides high reliability of predicting the progressive clinical course of glomerulonephritis in children by determining single-nucleotide polymorphisms of endothelin-1 (Lys198Asn), interleukin-4 (C-589T) and tumour necrosis factor (G308A) genes.

1 cl, 3 ex