METHOD OF EARLY PRE-CLINICAL DIAGNOSIS OF PARKINSON'S DISEASE Russian patent published in 2017 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, and can be used for diagnosis of Parkinson's disease at pre-clinical stage. Essence of method is that by method of HPLC following concentrations are determined in blood plasma: noradrenaline (NA), dopamine (DA), 3,4-dioxyphenylalanine (L-DOPA), 3,4-dioxyphenylacetic acid (DOPAA), comparison of concentration values with concentration preliminarily measured in healthy people. At reducing concentration by 57–67 % shaking form is diagnosed. At reducing concentration of noradrenaline by 80–90 % rigid form is diagnosed. At reducing concentration of DA in blood plasma by 69–79 % rigid form is diagnosed. At reducing concentration of L-DOPA by 57–67 % shaking form of Parkinson's disease is diagnosed. At reduction of L-DOPA by 78–88 % rigid form is diagnosed. At reducing concentration of DOPAA by 69–79 % rigid form of Parkinson's disease is diagnosed.

EFFECT: use of method enables high-accuracy diagnosing of various forms of Parkinson's disease at pre-clinical stage.

1 cl, 7 dwg