AGONISTS OF NEUROTROPHIN RECEPTORS AND THEIR USE AS MEDICAMENTS Russian patent published in 2017 - IPC C07K5/08 A61K38/06 A61P25/00 C07D207/04 C07D207/27 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of Formula (II), or pharmaceutically acceptable salts thereof, which have receptor agonists activity of neurotrophin. Formula (II) R₁ is phenyl substituted with halogen or trifluoromethyl and further optionally substituted with one or two substituents selected from the group, consisting of halogen, C_1-6 alkyl, (C_1-6)alkoxy and halo(C_1-6)alkyl; R₂ is 2-oxo-pyrrolidin-1-ylmethyl or sulfamoylphenyl.

EFFECT: invention relates to the pharmaceutical composition, method for production thereof, use of said compounds as an active ingredient for the manufacture of a drug for preventing or treating various diseases, as well as for preventing or treating nerve cell death or damage, methods for preventing or treating nerve cell death or damage, neuroprotection, regeneration of nerve cells, stimulation of the activity of brain-derived neurotrophic factor, methods for preventing or treating various diseases, including responsive to the stimulation of the activity of nerve growth factor, or a nerve growth factor receptor, neurotrophic factor or receptor of neurotrophic factor.

57 cl, 14 dwg, 17 ex