COMPOSITION OF COMPOUNDS AND WAYS OF THEIR APPLICATION Russian patent published in 2018 - IPC C07C15/28 C07D401/04 C07D401/14 A61K31/4545 A61K31/496 A61P35/00 

FIELD: medicine; biotechnology.

SUBSTANCE: invention relates to compounds having the structural formula (I): , or a salt or solvate thereof; where A¹ and A² independently are oxygen; R¹ is selected from the group consisting of hydrogen, NH₂; R² is selected from the group consisting of: , , R³, R⁵, R⁶ and R⁹ independently represent R^7th; R⁴ is selected from the group consisting of C_1–4haloalkyl, -(CHR)_nC(OH)(CF₃)₂, -C(O)OR¹¹, -SO₂NHC(=O)CH₃, -SO₂NH₂,

, , ; R⁷ is hydrogen; R¹¹ is independently selected from the group consisting of hydrogen, C_1–2alkyl or (CH₂)₂N(CH₃)₂; and n is 0; compounds having the structural formula (II): , where X is N or CH; R⁴ is selected from the group consisting of -C(O)OR¹¹, -C(CF₃)(CF₃)OH, -(CHR)_nC(OH)(CF₃)₂,

, , ; R¹¹ is selected from the group consisting of hydrogen, C_1–2alkyl or (CH₂)₂N(CH₃)₂; and n is 0; pharmaceutical compositions, containing them and to the use of such compounds in the treatment and/or prevention of certain types of cancer, pain, inflammation, restenosis, atherosclerosis, psoriasis, thrombosis, Alzheimer's disease, or dysfunction associated with dysmyelination or demyelination.

EFFECT: use of such compounds in the treatment and/or prevention of certain types of cancer, pain, inflammation, restenosis, atherosclerosis, psoriasis, thrombosis, Alzheimer's disease, or dysfunction associated with dysmyelination or demyelination.

20 cl, 4 tbl