FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, microbiology and immunology. Immunogenic composition is described, containing a plurality of capsular polysaccharides from serotypes of Streptococcus pneumoniae 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, conjugated with carrier-protein. Composition also contains at least one preservative, preferably 2-phenoxyethanol (2-PE). Immunogenic compositions containing preservative according to the invention provide resistance to one or more microorganisms and can be used for making multi-dose vaccines, having beneficial properties in terms of long-term stability of different antigen determinants of selected immunogenic composition.
EFFECT: disclosed group of inventions can be used in medicine.
27 cl, 15 dwg, 3 tbl, 6 ex
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