THE MIXED VACCINE, A METHOD OF SIMULTANEOUS MIXED VACCINATION AND A METHOD OF IMMUNOGENICITY INCREASE Russian patent published in 1998 - IPC

FIELD: medicine, vaccines. SUBSTANCE: vaccine has diphtheritic, tetanic, whooping cough antigens and a conjugate of fragments of capsule polysaccharides from Haemophilus influenza type b and protein CRM₁₉₇ in a single immunizing dose in pharmaceutically acceptable carrier. Diphtheritic and tetanic antigens can be in the form of the corresponding anatoxin. Whooping cough antigen can be in the form of inactivated cells Bordetella pertussis. Diphtheritic and tetanic anatoxins are adsorbed on aluminium phosphate. Inactivated cells Bordetella pertussis are administrated as suspension with potassium dihydrogen phosphate, sodium hydrogen phosphate and sodium chloride. The mixed vaccine is used for children vaccination by a single immunizing dose. EFFECT: enhanced effectiveness of immunogenicity of vaccine. 11 cl, 4 tbl