FIELD: pharmaceutics.
SUBSTANCE: invention relates to compound KC-8, which is N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or its pharmaceutically acceptable salts, solvates or hydrates, which provide controlled release of oxycodone by enzymatic decomposition with further intramolecular cyclization.
EFFECT: invention also relates to pharmaceutical compositions for use in treating or preventing pain, including compositions, additionally containing trypsin inhibitor, method of reducing potential misuse of said composition, standard dose containing said composition, method of its production and methods of selecting compounds and trypsin inhibitor, suitable for preparation of standard dose.
17 cl, 6 tbl, 8 dwg, 9 ex
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