FIELD: medicine.
SUBSTANCE: invention refers to a prodrug composition for treating diseases, disorders or conditions mediated by opioid binding to opioid receptors, containing a conjugate representing 3,6-diaspirin-hydromorphone in a pharmaceutically effective amount, and a biologically acceptable carrier. The invention also refers to a method of treating a patient suffering a disease, disorder or condition mediated by opioid binding to opioid receptors.
EFFECT: composition manifests improved bioavailability, lesser variability in an oral pharmacokinetic profile, lower peak plasma concentration and a lower probability of overdosage as compared to unconjugated hydromorphone.
12 cl, 21 dwg, 2 tbl, 7 ex
| Title |
Year |
Author |
Number |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND CONJUGATES OF HETEROARYL CARBOXYLIC ACID AND OXYMORPHONE, PRODRUGS, METHODS FOR OBTAINING AND USE THEREOF |
2015 |
- Martin, Andrea
- Kanski, Jaroslaw
- Bera, Sanjib
- Guenther, Sven
- Mickle, Travis
|
RU2683274C2 |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE |
2015 |
- Martin, Andrea K.
- Kanski, Jaroslaw
- Bera, Bindu
- Bera, Sanjib
- Guenther, Sven
- Mickle, Travis
|
RU2683317C2 |
| CONJUGATES OF HYDROCODONE WITH BENZOIC ACID, DERIVATIVES OF BENZOIC ACID AND HETERO-ACRYL-CARBON ACID, PRODRUGS, METHODS FOR THEIR OBTAINING AND APPLICATION |
2010 |
- Mikl Trevis
- Gjunter Sven
- Mikl Kristehl
- Chi Gochehn'
- Kan'Ski Jaroslav
- Martin Andrea K.
- Bera Bindu
|
RU2505541C2 |
| METHYLPHENIDATE PRODRUGS, METHODS OF THEIR OBTAINING AND APPLICATION |
2012 |
- Gjunter Sven
- Chi Gochehn'
- Bera Bindu
- Mikl Trevis
- Bera Sandzhib
|
RU2573835C2 |
| CONJUGATES OF THERAPEUTIC COMPOUND WITH FATTY ACID |
1996 |
- Robert Dzhordzh Uittehjker
- Veronika Dzhudit Bender
- Uehjn Gerrard Rejlli
- Minoo Mogkhaddam
|
RU2166512C2 |
| SYNERGETIC ANALGETIC COMBINATION OF OPIOID ANALGETIC AGENT AND CYCLOOXYGENASE-2 INHIBITOR |
1998 |
- Berch Ronal'D M.
- Goldenkhejm Pol D.
- Sakler Richard S.
|
RU2232600C2 |
| PHARMACEUTICAL COMPOSITIONS WITH REDUCED RELEASE OF PHENOL OPIOIDS |
2009 |
- Dzhenkins Tomas Eh.
- Serudzhi Dzhuli D.
- Rehj Dzhonatan V.
|
RU2562583C2 |
| METHOD FOR PREVENTION ABUSE WITH OPIOID- -CONTAINING MEDICINAL FORMULATIONS |
1998 |
|
RU2228180C2 |
| ABUSE-RESISTANT PHARMACEUTICAL COMPOSITIONS |
2015 |
- Rekhi, Gurvinder Singh
- Sidwell, Richard
|
RU2764569C2 |
| COMPOSITIONS COMPRISING ENZYME-CLEAVABLE KETONE-MODIFIED OPIOID PRODRUGS AND OPTIONAL INHIBITORS THEREOF |
2010 |
- Dzhenkins Tomas E.
- Khasfeld Krejg O.
- Serudzhi Dzhuli D.
- Rej Dzhonatan V.
|
RU2600736C2 |
