METHOD OF PRODUCTION OF RABIES DIAGNOSTIC SERUM Russian patent published in 2017 - IPC C12P21/00 A61K39/205 A61P31/12 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, specifically to immunology, and can be used for production of rabies diagnostic serum. For that immunization of animals-producers with antigen material and adjuvant is made. As adjuvant mixture of lanolin and polyethylsiloxane liquid is used, taken in weight ratio 1:2–9, respectively, immunomodulator immunofan in amount of 0.8–1.2 ml per one animal is additionally used. Immunization is performed 5 times, wherein at first three times every 20–24 hours antigen is introduced together with adjuvant, taken in weight ratio 1:0.8–1.0 in amount of 10–14 ml of mixture of antigen with adjuvant per one animal and simultaneously – immunofan. Then 12–16 days later antigen is introduced in amount of 5–7 ml of antigen per one animal and simultaneous immunofan, then 7–8 days later antigen is introduced in amount of 5–7 ml of antigen per one animal. Besides, method of producing rabies diagnostic serum uses polyethyl siloxane liquid PES-2 or PES-3 as polyethylsiloxane liquid, and antigen material is "sheep" strain of rabies virus VGNKI and reference strain CVS.

EFFECT: application of given method allows to increase target product quality due to increased specific activity of serum.

4 cl, 5 ex