VACCINE AGAINST PLAGUE, ADENOVIRUS INFECTIONS, PARVOVIRUS AND CORONAVIRUS ENTERITIS, LEPTOSPIROSIS AND RABIES OF DOGS Russian patent published in 2015 - IPC A61K39/295 A61P31/12 

FIELD: veterinary medicine.

SUBSTANCE: vaccine against plague, adenovirus infections, parvovirus and coronavirus enteritis, leptospirosis and rabies of dogs is proposed, containing the active ingredient and targeted additives, characterised in that as the active ingredient it comprises in 1 dose of vaccine the mixture of suspension of attenuated strain of canine distemper virus SCV No. 2313 family Paramyxoviridae, genus Morbillivirus with a titre of at least 10^3.5 TCD₅₀; suspension of attenuated strain of adenovirus of dogs of type 2 SCV No. 2311, family Adenoviridae, genus Mastadenovirus with a titre of at least 10^3.0 TCD₅₀; suspension of attenuated strain of canine parvovirus of type 2 SCV No. 2312, family Parvoviridae, genus Parvovirus with a titre of at least 10^3.0 HAU; suspension of attenuated strain of canine coronavirus SCV No. 2314, family Coronaviridae, genus Coronavirus with a titre of at least 10^3.0 TCD₅₀; inactivated suspension of strain of rabies of dogs ERA-CB-M20, family Rhabdoviridae, genus Lyssavirus in the amount of 1 ME, inactivated suspensions of leptospira of serogroups Icterohaemorrhagiae and Canicola taken in the mixture in equal proportions with the final concentration of each strain of at least 3×10⁸ inactivated microbial cells in 1 dose of the vaccine.

EFFECT: invention is characterised by higher antigenic and immunogenic potency, safety, ability to create colostral immunity of high intensity, high stability in storage, high specificity in relation to different subtypes and main antigenic variants of epizootic strains of pathogens circulating in the outer environment in the territory of Russia and the CIS countries, the vaccine is environmentally friendly, does not cause dissemination of pathogenic agents.

4 cl, 13 tbl, 8 ex