METHOD FOR PRODUCING 4(5)-NITROIMIDAZOLE Russian patent published in 2017 - IPC C07D233/92 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, namely, to a method for producing 4(5)-nitroimidazole, comprising imidazole nitration with sodium nitrate in sulphuric acid during heating, followed by cooling down, reaction mix neutralisation, and recovery of the target product; the reagent ratio is as follows: imidazole/H₂SO₄/NaNO₃ - 0.15:0.82:0.3, therefore 25% aqueous ammonia is used for neutralisation to achieve pH 10, the recovered product is refined by recrystallisation from water.

EFFECT: new method for producing 4(5)-nitroimidazole, an important compound used for synthesis of medicinal products; the method is characterised by high yield of the target product, improved process and its implementation, reduced energy and heat demand.

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