METHOD OF SYNTHESIS OF 2-METHYL-4(5)-NITRO-IMIDAZOLE Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 2-methyl-4(5)-nitroimidazole by nitration of 2- methylimidazole with nitric acid in the presence of sulfuric acid. Nitration reaction is carried out with nitrating mixture consisting of 52-60 wt. -% of sulfuric acid, 25-30 wt.-% of nitric acid and 15-18 wt.-% of water at 20-50 C. Invention can be used in pharmaceutical industry for preparing intermediate substance used for synthesis of medicinal preparation metronidazol. Invention provides the enhancement of selectivity of process, equipment and technological simplification of process, decreased consumption of heat and energy. EFFECT: improved method of synthesis. 2 cl, 1 tbl, 3 ex