METHOD FOR PRODUCTION OF DERIVATIVES OF 2-R-4(5)-NITRO IMIDAZOLES Russian patent published in 1995 - IPC

Abstract RU 2049780 C1

FIELD: pharmaceutical industry. SUBSTANCE: method involves production of derivatives of 2-R-4(5)-nitro imidazoles where R is H, -CH₃, -C_αH₅ by nitration. Said nitration of suitable 2-R-imidazoles is carried out in the medium of mineral acid. The process is followed by neutralization of reaction mass with the help of alkali agent and by isolation of desired product. Said nitration is carried out by solution of ammonium nitrate in the medium of nitric acid at 65-97 C within 1.5-6 h. Ratio (mass parts) imidazole:ammonium, nitrate: nitric, acid:water is 1:1.5-5.4:5.9-16.0:0.10-0.35 respectively. EFFECT: improves efficiency of method. 1 tbl

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RU 2 049 780 C1

Authors

Enin A.S.

Ushkova L.N.

Dodukh V.G.

Semenova A.A.

Egorenkov V.L.

Kochergin P.M.

Dates

1995-12-10—Published

1992-12-04—Filed