METHOD FOR ESTIMATION OF PROTECTIVE ACTION OF PHARMACOLOGICAL PREPARATION IN CASE OF ACUTE SENSORINEURAL HEARING LOSS IN EXPERIMENT Russian patent published in 2017 - IPC G09B23/28 A61B5/04 G01N33/50 

FIELD: medicine; pharmacology.

SUBSTANCE: to estimate protective action of pharmacological preparation in case of acute sensorineural hearing loss (ASNHL) in experiment under conditions of ASNHL models of different genesis before and after introduction of tested pharmacological preparation determined are amplitude and time characteristics of total electric response of cat's auditory analyser cochlea from round window membrane to short sound signal "click" with duration 3.1-0.2 ms with click intensity 30 dB above threshold of response detection. Content of glucose and lactate in labyrinth fluid of cochlea is also determined. If after introduction of preparation values of all determined indices approach values of such in cats in normal physiological state, protective action of pharmacological preparation is estimated as positive.

EFFECT: method makes it possible to objectively estimate different pharmacological preparations by their impact on cochlea function in suggested pathological models and identify single mechanism of ASNHL development at any pathological impact.

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