PHARMACEUTICAL KETOROLAC-BASED COMPOSITION IN FORM OF NASAL SPRAY AND METHOD FOR PREPARATION THEREOF Russian patent published in 2017 - IPC A61K9/12 A61K31/407 A61K47/48 A61P29/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry and represents a pharmaceutical composition in form of nasal spray, having analgesic and anti-inflammatory activity, characterized by the fact that it comprises tromethamine ketorolac as an active substance and additives: phenoxyethanol as a antimicrobial preserving agent and antiseptic, poloxamer 407 as a humidifier, disodium edetate as a chelating agent, sodium hydroxide and potassium dihydrogen phosphate as a buffer mixture and a pH regulator and water for injections, wherein ingredients of composition are taken in certain ratio, wt%.

EFFECT: invention ensures increased storage life after primary opening up to 20 days, in conditions of a refrigerating chamber, and at room temperature, wider range of nasal sprays, having analgesic and anti-inflammatory activity, as well as storage life of 2 years.

2 cl, 7 tbl