FIELD: medicine.
SUBSTANCE: invention is intended for early neonatal sepsis (ENS) diagnosis for newbornss of the first days of life. In the buccal scrape cells, expression levels of CD68 and IL12A genes are measured relative to the representation of mRNA reference V2M, GUS, TBP or HPRT genes. Based on the obtained expression levels, the canonical linear discriminant function (CLDF) value is calculated by the formula. If CLDF <0.45, a conclusion is made about the absence of infectious and inflammatory diseases. If CLDF> 0.45, ENS is defined.
EFFECT: invention provides an effective non-invasive ENS diagnosis.
3 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF SEPSIS FOLLOWING CARDIOSURGICAL OPERATIONS PERFORMED IN CONDITIONS OF ARTIFICIAL BLOOD CIRCULATION | 2019 |
|
RU2713930C1 |
| DIAGNOSTIC TECHNIQUE FOR VAGINITIS IN PREGNANT WOMEN BY INTERLEUKINE GENE IRNA EXPRESSION IN VAGINAL SMEARS | 2011 |
|
RU2510855C2 |
| METHOD OF PREDICTING DEVELOPMENT OF EARLY NEONATAL SEPSIS IN NEWBORNS WHOSE MOTHERS HAD COVID-19 DURING PREGNANCY | 2023 |
|
RU2813809C1 |
| EARLY DIAGNOSTIC TECHNIQUE FOR BACTERIAL PNEUMONIA COMBINED WITH RESPIRATORY DISTRESS SYNDROME OF PREMATURE NEWBORN | 2008 |
|
RU2382362C1 |
| METHOD FOR RPEDICTING INFECTIOUS-INFLAMATORY DISEASES IN NEONATALS BORN IN MOTHERS WITH ENDEMIC GOITER | 2005 |
|
RU2297000C1 |
| DIAGNOSTIC TECHNIQUE FOR PURULENT-SEPTIC COMPLICATIONS IN NEWBORNS | 2011 |
|
RU2484479C1 |
| METHOD FOR EARLY PREDICTION OF DEVELOPING NEONATAL PNEUMONIA IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT | 2020 |
|
RU2738577C1 |
| METHOD OF EARLY PREDICTION OF SEPTIC COMPLICATIONS IN NEWBORNS WITH RESPIRATORY PATHOLOGY | 2009 |
|
RU2414706C1 |
| METHOD FOR PREDICTING THE RISK OF INTESTINAL COLONIZATION BY KLEBSIELLA PNEUMONIAE IN PRETERM INFANTS IN THE NEONATAL PERIOD | 2022 |
|
RU2793050C1 |
| PREDICTION OF PREMATURE BIRTH BASED ON GENE EXPRESSION PROFILE OF INNATE IMMUNITY IN CERVICAL CELLS | 2016 |
|
RU2620153C1 |
