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2 613 582

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IPC

C07D487/04(2006-01-01)

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Application

2015155535, 2015-12-23

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Start date

2015-12-23

(22)

Actual filing date

2015-12-23

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Published

2017-03-17

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Inventor

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Professionalnogo Obrazovaniya Gosudarstvennyj Tekhnicheskij Universitet"

METHOD OF PRODUCING 2-SUBSTITUTED 1-HYDROXYPYRROLO[3,4-ƒ]INDOLE-5,7-(1H,6H)-DIONES Russian patent published in 2017 - IPC C07D487/04

Abstract RU 2613582 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 2-substituted 1-hydroxypyrrolo[3,4-ƒ]indole-5,7(1H,6H)-diones, where R=C₆H₅ or 4-CH₃C₆H₄, or 4-OCH₃C₆H₄, or 2-thienyl, which can be used as precursors for synthesis of biologically active substances, medicinal preparations, hexazocyclanes. Method of producing 2-substituted 1-hydroxypyrrolo[3,4-ƒ]indole-5,7(1H,6H)-diones includes two steps. At first step substituted 4-nitro-5-(2-oxoethyl)phthalonitriles are heated in a medium of polyphosphoric acid with density to form corresponding substituted 5-nitro-6-(2-oxoethyl-1H-isoindole-1,3(2H)-diones. At second step substituted 5-nitro-6-(2-oxoethyl)-1H-isoindole-1,3(2H)-diones are reduced with tin dichloride to obtain desired 2-substituted 1-hydroxypyrrolo[3,4-ƒ]indole-5,7(1H,6H)-diones.

EFFECT: use of disclosed method for synthesis of 2-substituted 1-hydroxypyrrolo[3,4-ƒ]indole-5,7(1H,6H)-diones enables to obtain novel, previously not described in literature indoles with an imide fragment.

1 cl, 4 ex

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RU 2 613 582 C1

Authors

Dates

2017-03-17—Published

2015-12-23—Filed