PHOSPHORUS AMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE APPLICABLE FOR TREATING CANCER Russian patent published in 2017 - IPC C07F9/6558 A61K31/675 A61P35/00 C07F9/24 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I) used in oncology, their pharmaceutically acceptable salts and compositions based on:

where Ar is phenyl or naphthyl and optionally substituted with -NO₂; R₃ is selected from benzyl, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, isopropyl, cyclohexyl, 2-indanyl, 3,3-dimethyl-1-butyl, cyclobutyl, cyclopropylmethyl, cyclopentyl, tetrahydropyranyl and 2,2-dimethylpropyl; R₄ is H atom; R₁ and R₂ are selected from H atom and C₁-C₁₆alkyl, optionally substituted with phenyl, or one of R₁ and R₂ has C₃-alkylene link connected to N atom so, that total number of ring atoms, including N and C atoms, is equal to 5 atoms, atom H, connected with N atom, is absent and one from R₁ and R₂ comprises atom H or C₁-C₁₆ alkyl; or pharmaceutically acceptable salt of compound of formula I, if said compound is not compound containing in combination unsubstituted phenyl as Ar, CH₃ as R₃, H as R₄, H as one of R₁ and R₂ and CH₃ as one of R₁ and R₂.

EFFECT: new effective anticancer agent and method of its production are presented.

67 cl, 11 dwg, 8 tbl, 8 ex