FIELD: medicine.
SUBSTANCE: invention relates to phosphoryl-substituted 3-keto-androst-4-ene-[16,17-d]pyridazines of general formula I, where R=Ph, NHPh or NHtBu.
EFFECT: creation of new steroid compounds with high antiproliferative activity against hormone-dependent breast cancer cells MCF7 and triple-negative breast cancer cells MDA-MB-231, which can be used in medicine to create antitumor agents.
3 cl, 4 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PHOSPHORUS AMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE APPLICABLE FOR TREATING CANCER | 2012 |
|
RU2614406C2 |
| N-PYPERONYL DERIVATIVES OF DAUNORUBICINE, WITH ANTIPROFLIFERATIVE PROPERTIES | 2017 |
|
RU2642068C1 |
| 2(,3(,5(-TRIHYDROXY-ANDROST-6-ONE, METHODS FOR ITS PRODUCTION AND APPLICATION | 2014 |
|
RU2629929C2 |
| SUBSTITUTED SPIRO ANDROSTENES-17, 6'[1,3,4]THIADIAZINES WITH ANTIVIRAL ACTIVITY | 2021 |
|
RU2750639C1 |
| FLUOROQUINOLONES BASED ON 4-DEOXYPYRIDOXINE | 2016 |
|
RU2634122C1 |
| (17S)-N-BENZYL-5-((3Β-ACETOXY-28-NOR-URS-12-ENE)-17-YL)-1,3,4-OXADIAZOL-2-AMINE, HAVING SELECTIVE CELL CYTOTOXICITY BREAST CANCER MCF-7 | 2019 |
|
RU2708400C1 |
| PYRIDOXIN AND ACETONE DERIVATIVES WITH ANTITUMOR ACTIVITY | 2017 |
|
RU2639879C1 |
| N-METHOXYBENZYL DERIVATIVES OF DAUNORUBICIN HAVING ANTIPROLIFERATIVE PROPERTIES | 2019 |
|
RU2704326C1 |
| CONJUGATES OF TRITERPENE ACIDS AND (E)-4-(1H-INDOLE-3-YLVINYL)-PYRIDINIUM BROMIDE WITH ANTITUMOR ACTIVITY | 2020 |
|
RU2786134C2 |
| FLUOROQUINOLONE COMPOUNDS BASED ON PYRIDOXINE DERIVATIVES, HAVING ANTIBACTERIAL PROPERTIES | 2019 |
|
RU2713932C1 |
