1,6-DIAZABICYCLO [3,2,1] OCTANE-7-ONA DERIVATIVES AND USE THEREOF FOR TREATING BACTERIAL INFECTIONS Russian patent published in 2017 - IPC C07D471/08 A61K31/439 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula (I), or to stereoisomer thereof, or to a pharmaceutically acceptable salt thereof, where R₁ is SO₃M; M is a hydrogen or Na; R₂ is (a) hydrogen or (b) (CH₂)_n-R₃; n equals 0 or 1; R₃ is (a) hydrogen, (b) C₁-C₆ alkyl, not necessarily substituted with one or a few substituents, independently selected from (a) 4-10-membered saturated or unsaturated heterocyclyl containing 1-3 heteroatoms, selected from nitrogen, oxygen and sulfur, not necessarily substituted with one or more substituents, independently selected from OH, CN, NHCOCF₃, NH₂, C(=NH)NH₂, oxo, C₁-C₆ alkyl, C₆H₅OH or pyrrolidine, (b) NH₂ or (c) NHC(=NH)NH₂,(c) 4-6-membered heterocyclyl containing 1 or 2 nitrogen atoms, not necessarily substituted with one or a few substituents, independently selected from CN or CONH₂. The invention also relates to a pharmaceutical composition based on the compound of formula (I), to a method of preventing or treating bacterial infection, based on injecting one compound of formula (I), as well as in a combination with another antibacterial agent. .

EFFECT: obtaining novel heterocyclic compounds, useful in the treatment of bacterial infections.

18 cl, 4 tbl, 51 ex