1,6-DIAZABICYCLO[3,2,1]OCTAN-7-ONE DERIVATIVES AND USING THEM FOR TREATING BACTERIAL INFECTIONS Russian patent published in 2016 - IPC C07D471/08 A61K31/439 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula (I), producing and using them in preventing or treating a bacterial infection. is formula (I), wherein R₁ represents (a) hydrogen, (b) (CO)_n-R₃, (c) COOR₄ or (d) COCH₂COR₃, n is equal to 0, 1 or 2; R₂ represents (a) SO₃M, (b) SO₂NH₂, (c) CH₂COOM or (d) CF₂COOM; M represents hydrogen or a cation; R₃ represents (a) hydrogen, (b) C₁-C₆-alkyl optionally substituted by one or more substitutes independently specified in halogen, OR₅, CN, CONR₆R₇, NR₆R₇, heterocyclyl, heteroaryl or aryl, (c) NR₆R₇, (d) CONR₆R₇, (e) heterocyclyl substituted by one or more substitutes independently specified in OR₅, NR₆R₇, halogen, CONR₆R₇, SO₂-alkyl, or NHC(NH)NR₆R₇, (f) heteroaryl optionally substituted by one or more substitutes independently specified in NR₆R₇, or CONR₆R₇, or (g) OR₈; R₄ represents (a) hydrogen or (b) C₁-C₆-alkyl; each R₅ and R₈ independently represent (a) hydrogen or (b) C₁-C₆-alkyl optionally substituted by one or more substitutes independently specified NR₆R₇ or heterocyclyl; each R₆ and R₇ independently represent (a) hydrogen or (b) R₆ and R₇ are attached to each other to form a four- to seven-merous ring.

EFFECT: producing the compounds for preventing or treating a bacterial infection.

36 cl, 8 tbl, 52 ex