1,6-DIAZABICYCLO[3,2,1]OCTAN-7-ONА DERIVATIVES AND USING THEM IN TREATING BACTERIAL INFECTIONS Russian patent published in 2015 - IPC C07D471/08 A61K31/4188 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new heterocyclic compound of general formula (I) or its stereoisomer, or its pharmaceutically acceptable salt, wherein Q means oxadiazol, thiadiazole or tetrazole; R₁ means: (b) (CO)_n-R₃ or (c) COOR₄, n=0 or 1; R₂ means SO₃M, M means hydrogen or cation; R₃ means: (a) C₁-C₆-alkyl optionally substituted by one or more substitute independently specified in halogen, NR₆R₇, heterocyclyl or aryl, (b) NR₆R₇, (c) CONR₆R₇, (d) aryl, (e) heterocyclyl, or (f) heteroaryl optionally substituted by CONR₆R₇, R₄ means (a) hydrogen, or (b) C₁-C₆-alkyl; each R₆ and R₇ independently means (a) hydrogen or (b) R₆ and R₇ are coupled together to form a four- to seven-merous ring, wherein cycloalkyl represents 3-7-merous cyclic hydrocarbon radical; heterocyclyl represents 4-7-merous cycloalkyl group containing one or more heteroatoms specified in nitrogen, oxygen or sulphur; aryl represents monocyclic or polycyclic hydrocarbon containing 6-14 atoms in the ring; heteroaryl represents monocyclic or polycyclic heteroaryl, wherein one or more carbon atoms are substituted by heteroatoms specified in nitrogen, oxygen or sulphur. The invention also refers to a pharmaceutical composition based on the compound of formula (I) and a method for preventing or treating a bacterial infection based on using the compound of formula (I).

EFFECT: produced are the new heterocyclic compounds effective in treating bacterial infections.

27 cl, 4 tbl, 28 ex