FIELD: biotechnology.
SUBSTANCE: present group of invention relates to biotechnology and immunology. Bispecifical binding protein is disclosed, which contains first polypeptide chain including two variable heavy chain domains of antibody and second polypeptide chain including two variable light chain domains of antibody (DVD-Ig). Disclosed protein binds human IL-1β and IL-1α. In addition recovered nucleic acid molecule, expression vector, host cell and method of producing binding protein under invention based on their using are disclosed. Besides pharmaceutical composition, methods of reducing activity of human IL-1 and method of treating patient from inflammatory disorder are presented.
EFFECT: protein under present invention has neutralizing activity with respect to human IL-1β and IL-1α and thus it can find further application in therapy of diseases associated with IL-1.
15 cl, 17 tbl, 4 ex
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