IL-1 ALPHA AND BETA BISPECIFIC IMMUNOGLOBULINS WITH DOUBLE VARIABLE DOMAINS AND THEIR APPLICATION Russian patent published in 2017 - IPC C07K16/24 C07K16/46 C12N15/13 C12N15/63 A61K39/395

Abstract RU 2627171 C2

FIELD: biotechnology.

SUBSTANCE: binding proteins, represented by immunoglobulins with double variable domains that bind IL-1α and IL-1β are claimed. In addition, the invention relates to methods for preparation, as well as application of these proteins, including as part of a pharmaceutical composition, for treatment of a disease or disorder in which the IL-1α and IL-1β or IL-1β activity is malicious.

EFFECT: invention allows IL-1α binding with IL-1β with high affinity .

32 cl, 2 dwg, 24 tbl, 2 ex

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RU 2 627 171 C2

Authors

Vu Chenbin

Dates

2017-08-03—Published

2011-12-20—Filed