METHOD FOR OBTAINING IMMUNOGLOBULIN PREPARATION FOR EXTERNAL APPLICATION Russian patent published in 2017 - IPC A61K39/395 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine and biotechnology and deals with method for obtaining immunoglobulin preparations, purified from admixtures with salts of metals from extracts of sediment B (Cohn III fraction). Method for obtaining immunoglobulin preparation for external application includes stage of extraction of sediment B (Cohn III fraction) with sodium chloride solution, removal of ballast admixtures and separation of target product by method of ultrafiltration in presence of complexing compounds. Removal of ballast admixtures is realised by successive treatment of extract first with merthiolate in concentration 0.1%, and then with copper sulphate in concentration 0.005-0.06% with pH value 8.0.

EFFECT: increase of clinical efficiency of immunoglobulin preparation for external application due to increased content of immunoglobulins of A and M classes, preservation of specific biological activity of preparation antibodies by improvement of technology of precipitation of ballast admixtures; elimination of toxic effect on patient and personnel by elimination of application of chloroform and polyethyleneglycol in precipitation of admixtures.

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