NANOPARTICLES CARRYING CHEMOTHERAPEUTIC ANTI-CANCER THERAPEUTIC AGENT Russian patent published in 2017 - IPC A61K31/704 A61K47/48 A61K47/30 A61K47/40 A61P35/00 B82B3/00 B82Y5/00

Abstract RU 2616494 C2

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to pharmaceutics, namely to method of treating hepatocellular carcinoma. Method of treating involves administering of nanoparticles to patient containing at least one chemotherapeutic anti-cancer agent representing doxorubicin, at least one poly(C₁-C₁₂alkylcyanoacrylate) and at least one cyclodextrin. Nanoparticles are administered by intravenous or intra-arterial infusion for at least 2 hours.

EFFECT: invention implementation allows to significantly reduce toxicological adverse effects of doxorubicin nanoparticles and to increase ratio of “benefit/risc”.

9 cl, 7 ex, 14 tbl

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RU 2 616 494 C2

Authors

Pizani Emiliya

Lebel-Bine Sofi

Polyar Valeri

Dates

2017-04-17—Published

2012-03-30—Filed