APOPTOSIS-INDUCING PREPARATIONS FOR TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Russian patent published in 2014 - IPC C07D405/12 C07D409/12 C07D409/14 C07D403/14 C07D401/12 C07D403/12 A61K31/496 A61K31/4709 A61K31/5377 A61K31/4523 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compound of formula or to its therapeutically acceptable salt, where A¹ represents N or C(A²); A² represents H; B¹ represents H, OR¹ or NHR¹; D¹ represents H; E¹ represents H; Y¹ represents CN, NO₂, F, Cl, Br, I, R¹⁷ or SO₂R¹⁷; R¹ represents R⁴ or R⁵; Z¹ represents R²⁶ or R²⁷; Z² represents R³⁰; Z^1A and Z^2A both are absent; L¹ represents R³⁷; R²⁶ represents phenylene; R²⁷ represents indolyl; R³⁰ represents piperasinyl; R³⁷ represents R^37A; R^37A represents C₂-C₄ alkylene; Z³ represents R³⁸, R³⁹ or R⁴⁰; R³⁸ represents phenyl; R³⁹ represents benzodioxilyl; R⁴⁰ represents C₄-C₇cycloalkenyl, heterocycloalkyl, which represents monocyclic six- or seven-member ring, containing one heteroatom, selected from O, and zero of double bonds, or azaspiro[5.5]undec-8-ene; the remaining values of radicals are given in i.1 of invention formula. Invention also relates to pharmaceutical composition, based on claimed compound.

EFFECT: novel compounds, which can be applied in medicine for treatment of diseases, in the process of which anti-apoptotic Bcl-2 protein is expressed, are obtained.

8 cl, 2 tbl, 411 ex