FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, comprising addition of methyl isobutyl ketone to an aqueous solution, containing 4-chloro-2-fluoro-3-methoxyphenylboronic acid, to obtain an organic phase, containing 4-chloro-2-fluoro-3-methoxyphenylboronic acid, and an aqueous phase; separation of organic phase, containing 4-chloro-2-fluoro-3-methoxyphenylboronic acid, from aqueous phase; reaction of 4-chloro-2-fluoro-3-methoxyphenylboronic acid with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate; and deacetylation of methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. Invention also relates to other versions of a method of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate and a method of extracting 4-chloro-2-fluoro-3-methoxyphenylboronic acid.
EFFECT: technical result: output of methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, obtained using disclosed method, increases, number of solvents, used in production, is reduced, complexity and cost of process is reduced.
23 cl, 6 ex
