FIELD: biotechnology.
SUBSTANCE: modified polynucleotide is proposed, encoding a pyruvate carboxylase (Pyc), wherein the initiating polynucleotide codon is replaced by ATG. An expression vector comprising the said modified polynucleotide is presented. Corynebacterium genus modified microorganism for L-lysine production is presented, which has an increased pyruvate carboxylase activity compared to its endogenous activity, where the initiating codon of the pyruvate carboxylase encoding polynucleotide is replaced by ATG.
EFFECT: group of inventions allows to obtain L-lysine with high productivity.
8 cl, 10 tbl, 11 ex
| Title |
Year |
Author |
Number |
| METHOD FOR L-LYSINE PRODUCTION USING MICROORGANISMS CAPABLE OF L-LYSINE PRODUCTION |
2012 |
- Lee Kwang Ho
- Lim Sang Jo
- Moon Jun Ok
- Jang Jae Woo
- Park Su Jin
- Park Sang Hee
|
RU2615454C1 |
| METHOD OF PRODUCING L-LYSINE USING MICROORGANISMS, CAPABLE OF PRODUCING L-LYSINE |
2012 |
- Lee Kwang Ho
- Lim Sang Jo
- Moon Jun Ok
- Jang Jae Woo
- Park Su Jin
- Park Sang Hee
|
RU2588665C2 |
| MICROORGANISM OF CORYNEBACTERIUM SPECIES HAVING ENHANCED L-LYSINE PRODUCIBILITY AND METHOD FOR PRODUCING L-LYSINE USING SAME |
2014 |
- Park Sang Hee
- Moon Jun Ok
- Bae Hyun Won
- Lee Kwang Ho
|
RU2667425C2 |
| GLUCONATE REPRESSOR VARIANT, L-LYSINE MICROORGANISM-PRODUCER THEREWITH AND METHOD FOR OBTAINING L-LYSINE BASED THEREON |
2016 |
- Park Sang Hee
- Kim Hyung Joon
- Kim Nam Hyun
- Moon Jun Ok
- Oh Jeong Seok
- Ryu Song-Gi
- Choi Hyang
|
RU2681475C1 |
| CORYNEBACTERIUM SPECIES MICROORGANISMS, HAVING CAPACITIES TO PRODUCE L-LYSINE, AND METHOD FOR PRODUCING L-LYSINE USING SAID MICROORGANISMS |
2016 |
- Byun Hyo Jeong
- Chung Yoon Hee
- Kim Hyung Joon
- Lee Sun Young
- Nam Hyun Koo
- Park Sun Mi
- Lee Sang Mok
|
RU2685482C1 |
| CORYNEBACTERIUM GENUS MICROORGANISM WITH IMPROVED ABILITY TO PRODUCE L-LYSINE AND METHOD FOR PRODUCING L-LYSINE USING SAME |
2014 |
- Moon Jun Ok
- Park Sang Hee
- Huh Lan
- Lee Kwang Ho
|
RU2651505C1 |
| METHOD OF PRODUCING AMINO ACIDS OF ASPARATE FAMILY WITH APPLICATION OF MICROORGANISMS |
2010 |
- Vittmann, Kristof
- Bekker, Judit
|
RU2535973C2 |
| MICROORGANISM HAVING IMPROVED L-LYSINE PRODUCING ABILITY AND METHOD FOR PRODUCING L-LYSINE BY USING SAID MICROORGANISM |
2015 |
- Lee, Peter
- Moon, Jun Ok
- Kim, Hyung Joon
- Ryu, Song Gi
|
RU2663135C2 |
| MICROORGANISMS OF CORYNEBACTERIUM SP., CAPABLE OF PRODUCING L-LYSINE, AND A METHOD FOR PRODUCING L-LYSINE USING SAID MICROORGANISMS |
2016 |
- Lee, Seung Bin
- Chung, Yoon Hee
- Kim, Hyung Joon
- Kang, Doo Jin
- Bang, Seong Eun
- Ryu, Song Gi
|
RU2687206C1 |
| MICROORGANISM FOR PRODUCING SIMULTANEOUSLY L-AMINO ACID AND RIBOFLAVIN AND METHOD FOR PRODUCTION OF L-AMINO ACID AND RIBOFLAVIN USING SAID METHOD |
2012 |
- Park Sang Hee
- Moon Jun Ok
- Lim Sang Jo
- Kwon Do Hyun
- Lee Kyung Han
- Sung Jin Suck
- Kim Hyung Joon
|
RU2588657C2 |
