FIELD: medicine, pharmacy.
SUBSTANCE: invention refers to chemical and pharmaceutical industry, and is an amplifier for the antitumor effect of an antitumor agent, comprising imidazooxaazine compound represented by trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo [1,2-c] pyrido [3,4-e] [1,3] oxazin-2-yl) phenyl)-cyclobutanol or trans-3-amino-1-cyclopropyl-3-(4- ( 3-phenyl-5H-imidazo [1,2-c] pyrido [4,3-e] [1,3] oxazin-2-yl)phenyl) cyclobutanol, or pharmaceutically acceptable salt thereof as an active ingredient. The invention also refers to pharmaceutical compositions, antitumor drugs containing the said compounds, applications, methods for the antitumor effect amplification and treatment of tumors.
EFFECT: invention provides a combined antitumor therapy, allowing to enhance the antitumor effect of anti tumor agents without substantial increase of toxicity.
18 cl, 77 ex, 22 tbl, 18 dwg
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