BRUTON'S TYROSINE KINASE INHIBITORS Russian patent published in 2017 - IPC C07D401/14 A61K31/502 A61K31/5377 A61P19/02 A61P29/00 A61P37/00 A61P11/06 

FIELD: pharmacy.

SUBSTANCE: invention relates to a compound of general formula I, below, or a pharmaceutically acceptable salt thereof. In the formula I compound, X is halogen; Y is H or lower alkyl; R is -R¹-R²-R³; R¹; R¹ is pyridyl; R² is -C (= O) or is absent; R³ is morpholinyl or pyrrolidinyl, optionally substituted by a lower alkyl. The above compounds are used to modulate OMB activity and treat diseases associated with excessive OMB activity. Furthermore, these compounds are used for treatment of inflammatory and autoimmune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. The invention also relates to the pharmaceutical composition comprising a compound of formula I and at least one carrier, diluent or excipient.

EFFECT: increased efficiency of compounds application.

20 cl, 2 tbl, 7 ex